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Scientist in Translational Medicine- Immuno-oncology - Gosselies (M/F)

October 23rd 2020

iTeos Therapeutics is a publicly-held (NASDAQ: ITOS), clinical-stage biopharmaceutical company dedicated to extending and improving the lives of cancer patients by designing and developing next generation immunotherapies. Based in Gosselies, Belgium and Cambridge, MA, iTeos Therapeutics was founded out of the Ludwig Institute for Cancer Research (LICR) and the de Duve Institute (UCLouvain) in 2011. In March 2020, the Company completed a $125 million Series B2 financing, and in July 2020, we completed our IPO raising over $200million of proceeds. This additional capital will allow us to continue to develop our clinical pipeline and expand our preclinical pipeline by investing in our discovery research team. Our innovative pipeline includes two clinical-stage programs targeting novel, validated immuno-oncology pathways. EOS-850, is designed as a highly selective small molecule antagonist of the adenosine A2a receptor, a key driver of immunosuppression in the tumor microenvironment across a broad range of tumors. EOS-850 is being investigated in an open-label Phase 1/2a clinical trial in adult patients with advanced solid tumors. The lead antibody product candidate, EOS-448, is an antagonist of TIGIT, also designed to engage the Fc gamma receptor, or FcγR,. An open-label Phase 1/2a clinical trial of EOS-448 is currently ongoing in adult patients with advanced solid tumors. The company also continues to expand its pipeline through internal research efforts and external collaboration with leading scientists.

Mission Description

KEYS RESPONSIBILITIES
As part of the wider translational medicine team, the successful candidate will play a key role in the evaluation of the mechanisms of action of our immune oncology drugs in clinical development and support the selection of biomarkers. In this role, the candidate will work independently and as part of a team to generate robust in vitro data on the products under clinical development, helping to interpret data obtained in clinical trials and refining our biomarker strategy. This is an exciting opportunity for a talented scientist eager to contribute in a meaningful way to the clinical development of innovative IO drugs for cancer patients.

YOUR MAIN RESPONSIBILITIES WILL BE TO:
Coordinate with colleagues from the translational medicine or pharmacology teams, design and perform independently complex experiments to assess the function and effect of iTeos drugs and to test new biomarkers in various immunology systems (i.e. immunophenotyping experiments, functional immunoassays as well as molecular biology and ELISA-based assays in human samples)
Identify and establish in the laboratory relevant immunoassays and technical approaches
Compile, document, critically analyse experimental results in order to present them at project subteam meetings
Show ownership by being up to date with the project literature and more broadly with the immune-oncology field 
Write technical reports and contribute to scientific articles
Share your expertise e.g. in immunoassays with other people and other teams within the company
Collaborate with external contacts, either with academic partners or with CRO’s

Candidate profile

  • PhD in immunology, preferably tumor immunology
  • Thorough understanding and proficient use of multi-parametric flow cytometry
  • Working knowledge with FACs Fortessa along with data analysis using FlowJo and DIVA software is highly desirable
  • Experience in cell culture including functional immunoassays (e.g. in vitro stimulation of immune cells)
  • Strong background in molecular biology assays (such as qRT-PCR, NGS is a plus) 
  • Previous experience in handling human blood samples and/or tissues for primary cell isolation is required
  • Ability to work with a high degree of autonomy
  • Ability to handle multiple collaborative projects and working in a fast-paced matrix environment
  • Multitasking, organization, record keeping, problem-solving skills are essential
  • Very good oral and written communication skills in English. French is a plus 
  • Knowledge of Microsoft Office is required. Experience in using analysis software (i.e. Prism) is a plus
  • Experience in working with SOPs and/or GCP and/or GCLP environment is a plus

Offer

  • A stimulating position within a high-potential and multi-cultural biotech company
  • The opportunity to work in a dynamic , respectful and professional environment
  • Extenstive networking inside the company, the biotech/pharma sector and the scientific world
  • A permanent contract and an attractive salary package in line with the position responsibilities and your experience

Contact Details

INTERESTED?
Send your CV together with an adapted cover letter to the following address: jobs@iteostherapeutics.com. Please, mention the reference RS-TM-IO in the mail object. Your application and related information will remain strictly confidential.

For our recruitments in Belgium, we closely collaborate with a Recruitment & Selection company, PaHRtners. Your application will be automatically forwarded to them. We, together with PaHRtners, will keep all your data confidential (GDPR compliant approach ).